Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | PDK2 | Q15119 | 12/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11469925 | 0.84 | THRB (1.00) | THRBTDP1PDK2CA1CA2 | |
| SCHEMBL66735 | 0.84 | THRB (1.00) | THRBTDP1PDK2CA1CA2 | |
| SCHEMBL30488775 | 0.84 | THRB (1.00) | THRBTDP1PDK2CA1CA2 | |
| Bromide SCHEMBL27743796 | 0.82 | THRB (0.95) | THRBTDP1PDK2CA1CA2 | |
| SCHEMBL9671734 | 0.81 | PDK2 (0.51) | THRBTDP1PDK2 | |
| SCHEMBL25134343 | 0.80 | THRB (0.70) | THRBTDP1PDK2CA1CA2 | |
| SCHEMBL68561 | 0.80 | THRB (0.70) | THRBTDP1PDK2 | |
| SCHEMBL30519841 | 0.80 | THRB (0.70) | THRBTDP1PDK2 | |
| Methyl Alcohol SCHEMBL21134117 | 0.80 | THRB (0.91) | THRBTDP1PDK2 | |
| Bromomethane SCHEMBL208217 | 0.78 | THRB (0.88) | THRBTDP1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137333-A2 | Spiro-tricyclicaromatic succinimide derivatives as inhibitors of aldose reductase | ALCON LABORATORIES, INC. (US) | 1985-04-17 | — | — | EP | disclosed |