Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 5/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11046905 | 0.97 | HRH4 (0.41) | HRH4CNR2ABCC1PIN1PDE4A | |
| SCHEMBL11044198 | 0.94 | HRH4 (0.43) | HRH4CNR2ABCC1PIN1PDE4A | |
| SCHEMBL10663243 | 0.89 | DAPK1 (0.43) | HRH4CNR2PIN1PDE4APDE4B | |
| SCHEMBL10972136 | 0.83 | ADK (0.42) | ABCC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10663201 | 0.83 | SLC29A1 (0.39) | — | |
| SCHEMBL10663797 | 0.82 | SLC29A1 (0.38) | CNR2ABCC1PDE4APDE4BPDE4C | |
| SCHEMBL10664114 | 0.82 | ADK (0.43) | ABCC1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10970639 | 0.82 | KDM4E (0.32) | ALDH1A1 | |
| SCHEMBL11052623 | 0.82 | HRH4 (0.41) | HRH4ABCC1CHRM1DAPK1ALDH1A1 | |
| SCHEMBL10661255 | 0.81 | NPC1 (0.36) | CNR2ABCC1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |