Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 3/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.39 |
| ▸ | TMIGD3 | P0DMS9 | 2/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HUWE1 | Q7Z6Z7 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664114 | 0.97 | ADK (0.43) | ADKADORA1ADORA3MAPTADORA2A | |
| SCHEMBL10660880 | 0.93 | NPSR1 (0.43) | ADKADORA1MAPTADORA2ATMIGD3 | |
| SCHEMBL10663431 | 0.87 | PDE4A (0.48) | ADORA1ADORA2ATMIGD3ADORA2BLMNA | |
| SCHEMBL11062725 | 0.86 | PDE4A (0.43) | ADKADORA1ADORA3ADORA2ATMIGD3 | |
| SCHEMBL10661153 | 0.86 | PDE5A (0.38) | MAPTLMNAPOLB | |
| SCHEMBL11049123 | 0.85 | PDE5A (0.39) | MAPTLMNAPOLB | |
| SCHEMBL10658083 | 0.84 | KHK (0.42) | LMNAHSD17B10NPSR1POLB | |
| SCHEMBL10662680 | 0.84 | CCNB2 (0.38) | TSHRLMNAHSD17B10NPSR1PDE4A | |
| SCHEMBL10970652 | 0.83 | HRH4 (0.44) | ABCC1ABCG2ABCB1TSHRPDE4A | |
| SCHEMBL8851152 | 0.83 | ADK (0.55) | ADKADORA1ADORA3MAPTADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0055444-B1 | TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1985-03-20 | — | — | EP | disclosed |
| US-4478833-A | ANTICOAGULANTS | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-10-23 | — | — | US | disclosed |
| EP-0055444-A2 | Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1982-07-07 | — | — | EP | disclosed |