Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GMNN | O75496 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | BLM | P54132 | 2/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.42 |
| ▸ | CMKLR1 | Q99788 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11762741 | 0.82 | ALDH1A1 (0.54) | LMNARAB9ACYP1A2CYP2A6PTPN1 | |
| SCHEMBL6324240 | 0.81 | CYP2A6 (0.53) | RAB9ACYP1A2CYP2A6CNR2KMT2A | |
| SCHEMBL10970254 | 0.81 | CNR2 (0.50) | LMNACYP1A2CYP2A6CNR2PTPN1 | |
| SCHEMBL8948846 | 0.80 | MTNR1A (0.46) | LMNARAB9ACYP1A2CYP2A6CNR2 | |
| SCHEMBL3391575 | 0.80 | NR4A1 (0.60) | RAB9ACYP1A2CYP2A6CNR2PTPN1 | |
| SCHEMBL6303548 | 0.80 | CYP2A6 (0.55) | RAB9ACYP1A2CYP2A6CNR2MAPT | |
| SCHEMBL5131018 | 0.79 | PTPN1 (0.67) | LMNACYP1A2PTPN1MAPTMITF | |
| SCHEMBL6914678 | 0.78 | NR4A1 (0.58) | RAB9ACYP1A2CYP2A6CNR2PTPN1 | |
| SCHEMBL6916300 | 0.78 | NR4A1 (0.58) | RAB9ACYP1A2CYP2A6CNR2PTPN1 | |
| SCHEMBL6915657 | 0.78 | NR4A1 (0.58) | RAB9ACYP1A2CYP2A6CNR2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016587-B1 | 1-((SUBSTITUTED-NAPHTHYL)ETHYL)-IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHODS OF MAKING THEM | SYNTEX (U.S.A.) INC. (US) | 1985-06-19 | — | — | EP | disclosed |
| US-4423057-A | ANTISECRETORY, ANTICONVULSANT | SYNTEX (U.S.A.) INC. (US) | 1983-12-27 | — | — | US | disclosed |
| US-4277486-A | ANTICONVULSANTS, ANTISECRETORY AGENTS, SPERMATOCIDES | SYNTEX (U.S.A.) INC. (US) | 1981-07-07 | — | — | US | disclosed |
| EP-0016587-A1 | 1-((Substituted-naphthyl)ethyl)-imidazole derivatives, pharmaceutical compositions containing them and methods of making them | SYNTEX (U.S.A.) INC. (US) | 1980-10-01 | — | — | EP | disclosed |