Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.68 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | NPC1 | O15118 | 5/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10763947 | 0.83 | RAB9A (0.68) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10763655 | 0.82 | LMNA (0.67) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10764421 | 0.82 | RAB9A (0.67) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10763657 | 0.82 | RAB9A (0.71) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10765743 | 0.82 | RAB9A (0.67) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10761784 | 0.82 | SMN1; SMN2 (0.71) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10762783 | 0.81 | LMNA (0.62) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10996605 | 0.81 | PTGS1 (1.00) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10977879 | 0.80 | SMN1; SMN2 (0.59) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA | |
| SCHEMBL10762199 | 0.78 | RAB9A (0.66) | PTGS1PTGS2SMN1; SMN2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4508721-A | Pyridazin-3-one derivatives | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-04-02 | — | — | US | claimed |
| EP-0081906-A1 | Pharmaceutically-active pyridylvinylpyridazinones | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-22 | — | — | EP | claimed |
| EP-0081906-B1 | PHARMACEUTICALLY-ACTIVE PYRIDYLVINYLPYRIDAZINONES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-07-24 | — | — | EP | disclosed |
| US-4508721-A | Pyridazin-3-one derivatives | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1985-04-02 | — | — | US | disclosed |
| EP-0081906-A1 | Pharmaceutically-active pyridylvinylpyridazinones | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-06-22 | — | — | EP | disclosed |