SCHEMBL10972729

SCHEMBL10972729

CCOC(=O)CCCNc1cc(OC)c(OC)cc1C(C)=O

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNF P01375 12/20 0.51
KDM4E B2RXH2 2/20 0.47
MAPT P10636 1/20 0.47
TOP2A P11388 1/20 0.43
HTT P42858 1/20 0.41
ALDH1A1 P00352 2/20 0.40
APAF1 O14727 1/20 0.40
TDP2 O95551 1/20 0.40
GAA P10253 1/20 0.40
MAPK1 P28482 1/20 0.40
CASP3 P42574 1/20 0.40
SENP8 Q96LD8 1/20 0.40
HSD17B10 Q99714 1/20 0.40
SENP7 Q9BQF6 1/20 0.40
SENP6 Q9GZR1 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C19 P33261 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10971694 0.96 TNF (0.50) TNFKDM4EMAPTTOP2AHTT
SCHEMBL10969965 0.92 TNF (0.47) TNFKDM4EMAPTTOP2AHTT
SCHEMBL10983478 0.84 HTT (0.45) KDM4EMAPTHTTALDH1A1APAF1
SCHEMBL8349172 0.81 HTT (0.50) KDM4EMAPTHTTALDH1A1APAF1
SCHEMBL10738708 0.78 TDP1 (0.49) KDM4EMAPTHTTALDH1A1MAPK1
SCHEMBL8350121 0.77 HTT (0.53) KDM4EMAPTHTTALDH1A1GAA
SCHEMBL17742699 0.75 TNF (0.52) TNFMAPTHTTKMT2ACYP3A4
SCHEMBL7413878 0.75 ALDH1A1 (0.60) KDM4EMAPTHTTALDH1A1MAPK1
SCHEMBL7290704 0.74 TSHR (0.57) KDM4EMAPTHTTALDH1A1MAPK1
SCHEMBL405745 0.74 TDP1 (0.45) TNFKDM4EMAPTTOP2AHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4556739-A QUINAZOLINONE INTERMEDIATES ORTHO PHARMACEUTICAL CORPORATION (US) 1985-12-03 US disclosed
EP-0138492-A2 Process for preparing substituted 4-alkyl-2(1H) quinazolinone-1-alkanoic acid derivatives ORTHO PHARMACEUTICAL CORPORATION (US) 1985-04-24 EP disclosed