Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4958399 | 0.91 | AKR1B1 (0.51) | C5AR1AKR1B1 | |
| SCHEMBL10978203 | 0.85 | SCN9A (0.54) | — | |
| SCHEMBL16166478 | 0.84 | C5AR1 (0.47) | C5AR1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4961382 | 0.84 | PTGDR2 (0.54) | AKR1B1 | |
| SCHEMBL4962400 | 0.82 | PTGDR2 (0.53) | AKR1B1 | |
| SCHEMBL10804112 | 0.81 | APAF1 (0.47) | AKR1B1 | |
| SCHEMBL10974094 | 0.81 | PTGDR2 (0.61) | AKR1B1 | |
| SCHEMBL4961366 | 0.79 | PTGDR2 (0.61) | AKR1B1 | |
| SCHEMBL10975116 | 0.78 | AKR1B1 (0.78) | AKR1B1 | |
| SCHEMBL4960118 | 0.78 | PTGDR2 (0.64) | AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4523021-A | ANTIDIABETIC AND ANTIGLACTOSEMIA AGENT | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-06-11 | — | — | US | disclosed |
| EP-0065407-B1 | PHARMACEUTICAL SPIRO-SUCCINIMIDE DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-03-13 | — | — | EP | disclosed |
| US-4478847-A | ALDOSE REDUCTASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-23 | — | — | US | disclosed |
| EP-0065407-A2 | Pharmaceutical spiro-succinimide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-11-24 | — | — | EP | disclosed |