Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973431 | 0.84 | C5AR1 (0.53) | C5AR1LMNAPOLBSMN1; SMN2 | |
| SCHEMBL4958399 | 0.75 | AKR1B1 (0.51) | C5AR1PTGDR2 | |
| SCHEMBL16166357 | 0.75 | SCN9A (0.46) | MEN1KMT2APTGDR2MAPTHTR1A | |
| SCHEMBL16166319 | 0.74 | PTGDR2 (0.47) | PTGDR2SCN9A | |
| SCHEMBL16166561 | 0.72 | PTGDR2 (0.36) | PTGDR2 | |
| SCHEMBL10978203 | 0.69 | SCN9A (0.54) | MAPTTP53SCN9A | |
| SCHEMBL4961382 | 0.69 | PTGDR2 (0.54) | PTGDR2 | |
| SCHEMBL4962400 | 0.67 | PTGDR2 (0.53) | PTGDR2 | |
| SCHEMBL10804112 | 0.66 | APAF1 (0.47) | KMT2AMAPTTP53SCN9A | |
| SCHEMBL10974094 | 0.66 | PTGDR2 (0.61) | PTGDR2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |