Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | HBB | P68871 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TNF | P01375 | 7/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.32 |
| ▸ | PDE4A | P27815 | 2/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977463 | 0.74 | TP53 (0.46) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| SCHEMBL11355379 | 0.73 | TP53 (0.49) | TP53HBBSMN1; SMN2PDE4APDE4B | |
| Teroxirone SCHEMBL4470513 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| Teroxirone SCHEMBL4461477 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| Teroxirone SCHEMBL4472568 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| Teroxirone SCHEMBL2097375 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| Teroxirone SCHEMBL2097151 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| Teroxirone SCHEMBL4452999 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| Teroxirone SCHEMBL4932 | 0.71 | TP53 (1.00) | TP53HBBSMN1; SMN2DHFRCDK4 | |
| SCHEMBL5435485 | 0.70 | TNF (0.53) | SMN1; SMN2TNFTSHRALDH1A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4463006-A | ANTICANCER, ANTITUMOR AGENTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1984-07-31 | — | — | US | claimed |
| EP-0071903-B1 | DIGLYCIDYL PTERIDINE COMPOUNDS, METHOD FOR THEIR PREPARATION AND THEIR USE IN DRUGS WITH A CYTOSTATIC ACTIVITY | Henkel Kommanditgesellschaft auf Aktien (DE) | 1985-08-28 | — | — | EP | disclosed |
| US-4463006-A | ANTICANCER, ANTITUMOR AGENTS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1984-07-31 | — | — | US | disclosed |
| EP-0071903-A1 | Diglycidyl pteridine compounds, method for their preparation and their use in drugs with a cytostatic activity | Henkel Kommanditgesellschaft auf Aktien (DE) | 1983-02-16 | — | — | EP | disclosed |