Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 4/20 | 0.39 |
| ▸ | NOS2 | P35228 | 4/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 2/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370193 | 0.89 | FAAH (0.38) | NOS1NOS2FAAHNOS3MEN1 | |
| SCHEMBL3942028 | 0.84 | — | — | |
| SCHEMBL29886436 | 0.84 | — | — | |
| SCHEMBL15423555 | 0.84 | — | — | |
| SCHEMBL2051321 | 0.84 | — | — | |
| SCHEMBL528992 | 0.79 | NOS1 (0.46) | NOS1NOS2FAAHNOS3MEN1 | |
| SCHEMBL21297485 | 0.79 | NOS1 (0.46) | NOS1NOS2FAAHNOS3MEN1 | |
| SCHEMBL7157465 | 0.77 | NOS1 (0.44) | NOS1NOS2FAAHNOS3MEN1 | |
| SCHEMBL5064686 | 0.77 | NOS1 (0.44) | NOS1NOS2FAAHNOS3MEN1 | |
| SCHEMBL10502755 | 0.77 | NOS1 (0.44) | NOS1NOS2FAAHNOS3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4546104-A | Pyrazolopyridine cycloalkanones and process for their preparation | ICI AMERICAS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0141608-A2 | Pyrazolopyridine cycloalkanone derivatives | ICI AMERICAS INC. (US) | 1985-05-15 | — | — | EP | disclosed |