Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973574 | 0.81 | HSD17B10 (0.66) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL1029180 | 0.79 | HSD17B10 (1.00) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL16011599 | 0.78 | L3MBTL1 (0.50) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL21054591 | 0.77 | HSD17B10 (0.65) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6394768 | 0.77 | HSD17B10 (0.59) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL6392624 | 0.76 | RAB9A (0.53) | HSD17B10SMN1; SMN2RAB9ANPC1L3MBTL1 | |
| SCHEMBL7508433 | 0.76 | HSD17B10 (0.50) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3070666 | 0.76 | HSD17B10 (0.70) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 | |
| SCHEMBL13752162 | 0.74 | RAB9A (0.70) | HSD17B10SMN1; SMN2RAB9ANPC1L3MBTL1 | |
| SCHEMBL5106178 | 0.74 | MAPK1 (1.00) | HSD17B10MAPK1SMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0033195-B1 | PYRIMIDINE-2-SULPHIDES AND THEIR S-OXIDES FOR USE IN MEDICINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCESSES FOR THEIR PREPARATION AND SUCH COMPOUNDS WHEN NOVEL PER SE | NYEGAARD & CO. A/S (NO) | 1985-12-04 | — | — | EP | disclosed |
| US-4423047-A | INHIBITING ABNORMAL CELL PROLIFERATION | NYEGAARD & CO. A/S (NO) | 1983-12-27 | — | — | US | disclosed |
| EP-0033195-A1 | Pyrimidine-2-sulphides and their S-oxides for use in medicine, pharmaceutical compositions containing them, processes for their preparation and such compounds when novel per se | NYEGAARD & CO. A/S (NO) | 1981-08-05 | — | — | EP | disclosed |