Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 5/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5339681 | 0.76 | KEAP1 (0.39) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL7871768 | 0.73 | EPHX1 (0.37) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL29037985 | 0.71 | KEAP1 (0.40) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL873007 | 0.70 | KEAP1 (0.42) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL8328164 | 0.70 | KEAP1 (0.42) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL2846765 | 0.70 | KEAP1 (0.42) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL22341281 | 0.70 | KEAP1 (0.38) | KEAP1NFE2L2ALDH1A1CES2TP53 | |
| SCHEMBL2788657 | 0.69 | KEAP1 (0.59) | KEAP1NFE2L2ALDH1A1TSHRNPC1 | |
| SCHEMBL21269265 | 0.69 | KEAP1 (0.41) | KEAP1NFE2L2ALDH1A1CES2CES1 | |
| SCHEMBL21269428 | 0.69 | KEAP1 (0.41) | KEAP1NFE2L2ALDH1A1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0155981-A2 | Derivatives of alkoxythiophenol; alkoxyphenolthio carbamates | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-02 | — | — | EP | disclosed |