Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.48 |
| ▸ | HPGD | P15428 | 8/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.43 |
| ▸ | CASP7 | P55210 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10979981 | 0.94 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL11236328 | 0.91 | KDM4E (0.47) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10977751 | 0.90 | ALDH1A1 (0.46) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL10981081 | 0.88 | CACNA1C (0.52) | ALDH1A1KDM4EHPGDNPSR1GAA | |
| SCHEMBL10811341 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL10973525 | 0.87 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10975527 | 0.86 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10811335 | 0.86 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| SCHEMBL10972608 | 0.86 | HSD17B10 (0.45) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10977470 | 0.85 | HSD17B10 (0.44) | ALDH1A1KDM4EHPGDNPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4321384-A | Antihypertensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-03-23 | — | — | US | claimed |
| EP-0059291-B1 | ANTIHYPERTENSIVE AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1985-03-27 | — | — | EP | disclosed |
| EP-0059291-A1 | Antihypertensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-09-08 | — | — | EP | disclosed |
| US-4321384-A | Antihypertensive agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1982-03-23 | — | — | US | disclosed |