⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28303304 | 0.98 | — | — | |
| SCHEMBL4685916 | 0.93 | TBXAS1 (0.75) | — | |
| SCHEMBL9640710 | 0.91 | TBXAS1 (0.79) | — | |
| SCHEMBL25320746 | 0.91 | TBXAS1 (0.79) | — | |
| SCHEMBL25315015 | 0.91 | TBXAS1 (0.79) | — | |
| SCHEMBL25322190 | 0.91 | TBXAS1 (0.79) | — | |
| SCHEMBL6267092 | 0.91 | TBXAS1 (0.79) | — | |
| SCHEMBL181658 | 0.86 | — | — | |
| SCHEMBL937596 | 0.85 | TBXAS1 (0.95) | — | |
| SCHEMBL9777196 | 0.85 | TBXAS1 (0.85) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 215 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101801949-B | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | claimed |
| EP-2183239-B1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-22 | — | — | EP | claimed |
| US-8153682-B2 | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA, NV (BE) | 2012-04-10 | — | — | US | claimed |
| CN-101801949-A | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2010-08-11 | — | — | CN | claimed |
| EP-2183239-A1 | SULFONAMIDES AS TRPM8 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2010-05-12 | — | — | EP | claimed |
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-10-22 | — | — | US | claimed |
| CN-101423513-A | Amine pyrimidine derivates, and production method thereof, and medicament composition and use | INST MATERIA MEDICA CAMS (CN) | 2009-05-06 | — | — | CN | claimed |
| WO-2009012430-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-22 | — | — | WO | claimed |
| US-7186710-B2 | Phthalazinones | ALTANA PHARMA AG (DE) | 2007-03-06 | — | — | US | claimed |
| CN-1854130-A | Chinazoline derivative, its production, medicinal composition and use | PHARMACEUTICAL INST CHINA ACAD (CN) | 2006-11-01 | — | — | CN | claimed |
| US-6846827-B1 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-01-25 | — | — | US | claimed |
| EP-1226126-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-01-05 | — | — | EP | claimed |
| US-20040127707-A1 | PDE4/7 inhibitors useful in treatment of airway disorders, autoimmune system disorders, skin disorders, arthritis, nerve system disorders | ALTANA PHARMA AG (DE) | 2004-07-01 | — | — | US | claimed |
| EP-1385848-A2 | PHTALAZINONES DERIVATIVES USEFUL AS PDE4/7 INHIBITORS | ALTANA Pharma AG (DE) | 2004-02-04 | — | — | EP | claimed |
| WO-2002085906-A2 | PHTHALAZINONES DERIVATIVES USEFUL AS PDE4/7 INHIBITORS | ALTANA PHARMA AG (DE) | 2002-10-31 | — | — | WO | claimed |
| EP-0450066-B1 | CARBOSTYRIL DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 1996-09-11 | — | — | EP | claimed |
| US-4839352-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1989-06-13 | — | — | US | claimed |
| CN-111182898-B | Methods for treating huntington's disease | PTC医疗公司 | 2024-04-16 | — | — | CN | disclosed |
| EP-0001265-A1 | O-, N- and carboxyl derivatives of thienamycin sulfoxide and sulfone, their preparation and pharmaceuticals containing said compounds | MERCK & CO. INC. (US) | 1979-04-04 | — | — | EP | disclosed |
| EP-0001264-A1 | Substituted N-methylene derivatives of thienamycin sulfoxide and sulfone and their preparation | MERCK & CO. INC. (US) | 1979-04-04 | — | — | EP | disclosed |