SCHEMBL10977652

SCHEMBL10977652

O=C1C(=O)N(CCCCCl)c2ccccc21

nearest known ligand 0.83

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.71
ALDH2 P05091 4/20 0.71
ALDH3A1 P30838 4/20 0.71
CES1 P23141 8/20 0.71
BCHE P06276 3/20 0.71
CDC25A P30304 1/20 0.69
PKM P14618 1/20 0.65
TGM2 P21980 1/20 0.61
PARK7 Q99497 1/20 0.59
CHRM1 P11229 2/20 0.58
ACHE P22303 1/20 0.55
TP53 P04637 1/20 0.55
CES2 O00748 1/20 0.54
MAOA P21397 1/20 0.53
MAOB P27338 1/20 0.53
CHRM5 P08912 1/20 0.53
CHRM3 P20309 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4597174 0.98 CES1 (0.72) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL2149622 0.95 CES1 (0.73) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL25119569 0.91 CES1 (0.85) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL25119255 0.90 CES1 (0.84) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL7824511 0.88 CES1 (0.79) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL19924204 0.84 CES1 (1.00) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL281625 0.83 ALDH1A1 (1.00) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL11148969 0.83 CES1 (0.78) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL281618 0.83 CES1 (0.76) ALDH1A1ALDH2ALDH3A1CES1BCHE
SCHEMBL2149331 0.83 CES1 (0.83) ALDH1A1ALDH2ALDH3A1CES1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0060610-B1 HEXAHYDRO-TRANS- AND TETRAHYDROPYRIDOINDOLE NEUROLEPTIC AGENTS PFIZER INC. (US) 1985-09-04 EP disclosed
US-4432978-A NEUROLEPTIC AGENTS, TRANQUILIZERS PFIZER INC. (US) 1984-02-21 US disclosed
US-4431649-A TRANQUILIZERS PFIZER INC. (US) 1984-02-14 US disclosed
US-4431646-A TRANQUILIZERS; PSYCHOSIS; NERVOUS SYSTEM DISORDERS PFIZER INC. (US) 1984-02-14 US disclosed
US-4427679-A TRANQUILIZERS; PSYCHOLOGICAL DISORDERS PFIZER INC. (US) 1984-01-24 US disclosed
EP-0060610-A1 Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents PFIZER INC. (US) 1982-09-22 EP disclosed
US-4337250-A NEUROLEPTIC AGENTS PFIZER INC. (US) 1982-06-29 US disclosed