Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 8/20 | 0.72 |
| ▸ | CDC25A | P30304 | 1/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.69 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.69 |
| ▸ | BCHE | P06276 | 3/20 | 0.69 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | TGM2 | P21980 | 1/20 | 0.59 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10977652 | 0.98 | ALDH1A1 (0.71) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL2149622 | 0.93 | CES1 (0.73) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL25119255 | 0.92 | CES1 (0.84) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL25119569 | 0.90 | CES1 (0.85) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL7824511 | 0.86 | CES1 (0.79) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL29821573 | 0.84 | CDC25A (1.00) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL282035 | 0.84 | CDC25A (1.00) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL11149607 | 0.84 | CES1 (0.76) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL29613389 | 0.84 | CDC25A (1.00) | CES1CDC25AALDH1A1ALDH2ALDH3A1 | |
| SCHEMBL3016105 | 0.84 | CDC25A (1.00) | CES1CDC25AALDH1A1ALDH2ALDH3A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008046083-A2 | USE OF OXINDOLE COMPOUNDS AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-04-17 | — | — | WO | disclosed |
| EP-1877378-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2008-01-16 | — | — | EP | disclosed |
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC. (CA) | 2007-05-10 | — | — | US | disclosed |
| WO-2006113864-A2 | OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2006-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070105820-A1 | Oxindole compounds and their uses as therapeutic agents | OPRL1, OPRK1, TRPV1 | CES1 4183/4885CDC25A 3151/4885ALDH1A1 1136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.