⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881706 | 0.79 | — | — | |
| SCHEMBL8617913 | 0.79 | — | — | |
| Methylene Chloride SCHEMBL27703541 | 0.79 | KDM4E (0.80) | — | |
| Bromide SCHEMBL4803852 | 0.78 | KDM4E (0.59) | — | |
| SCHEMBL13137557 | 0.76 | KDM4E (0.52) | — | |
| SCHEMBL248687 | 0.76 | — | — | |
| SCHEMBL28230831 | 0.75 | — | — | |
| SCHEMBL4532908 | 0.75 | KDM4E (0.67) | — | |
| SCHEMBL12694508 | 0.75 | KDM4E (0.50) | — | |
| SCHEMBL5158134 | 0.73 | KDM4E (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2738163-B1 | AMIDINE COMPOUND OR SALT THEREOF | TAISHO PHARMACEUTICAL CO LTD (JP) | 2016-01-20 | — | — | EP | disclosed |
| EP-2738163-B1 | AMIDINE COMPOUND OR SALT THEREOF | TAISHO PHARMACEUTICAL CO LTD (JP) | 2016-01-20 | — | — | EP | disclosed |
| US-9045466-B2 | Amidine compound or salt thereof | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2015-06-02 | — | — | US | disclosed |
| US-9045466-B2 | Amidine compound or salt thereof | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2015-06-02 | — | — | US | disclosed |
| US-9045466-B2 | Amidine compound or salt thereof | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2015-06-02 | — | — | US | disclosed |
| US-20140155597-A1 | AMIDINE COMPOUND OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2014-06-05 | — | — | US | disclosed |
| US-20140155597-A1 | AMIDINE COMPOUND OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2014-06-05 | — | — | US | disclosed |
| US-20140155597-A1 | AMIDINE COMPOUND OR SALT THEREOF | TOYAMA CHEMICAL CO., LTD. (JP) | 2014-06-05 | — | — | US | disclosed |
| EP-2738163-A1 | AMIDINE COMPOUND OR SALT THEREOF | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-06-04 | — | — | EP | disclosed |
| EP-2738163-A1 | AMIDINE COMPOUND OR SALT THEREOF | Taisho Pharmaceutical Co., Ltd. (JP) | 2014-06-04 | — | — | EP | disclosed |
| CN-1012365-B | 2- (N-substituted guanidino) -4-heteroaryl thiazole antiulcer agent and its preparation method | PFIZER (US) | 1991-04-17 | — | — | CN | disclosed |
| CN-85103265-A | The method of preparation 2-(guanidine radicals that N-replaces)-4-heteroaryl thiazole anti ulcer agent | — | 1986-12-10 | — | — | CN | disclosed |
| US-4560690-A | ANTISECRETORY AGENTS, HISTAMINE H2-ANTAGONISTS | PFIZER INC. (US) | 1985-12-24 | — | — | US | disclosed |
| EP-0161841-A1 | 2-(N-substituteguanidino)-4-hetero-arylthiazole antiulcer agents | PFIZER INC. (US) | 1985-11-21 | — | — | EP | disclosed |
| US-4258040-A | Cephalosporin compounds | MERCK & CO., INC. (US) | 1981-03-24 | — | — | US | disclosed |
| US-4060687-A | Cephalosporins having a 3-α substituted alkyl grouping | MERCK & CO., INC. (US) | 1977-11-29 | — | — | US | disclosed |
| US-3947413-A | ANTIBIOTICS | MERCK & CO., INC. (US) | 1976-03-30 | — | — | US | disclosed |