Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 7/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.37 |
| ▸ | DRD3 | P35462 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10985132 | 0.85 | HCN4 (0.73) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10986664 | 0.85 | HCN4 (0.72) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL11092035 | 0.85 | HCN4 (0.61) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10984472 | 0.84 | HCN4 (0.60) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL11263213 | 0.83 | HCN4 (0.72) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL11088902 | 0.81 | HCN4 (0.50) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL10980734 | 0.80 | HCN4 (0.58) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL10599539 | 0.80 | HCN4 (0.65) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| Hydrochloric Acid SCHEMBL10988254 | 0.79 | HCN4 (0.57) | HCN4BRD4MAPTCYP3A4ALOX15 | |
| SCHEMBL11091288 | 0.79 | HCN4 (0.55) | HCN4BRD4MAPTCYP3A4ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0065229-B1 | BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND THEIR APPLICATION AS PHARMACEUTICAL PREPARATIONS | Dr. Karl Thomae GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |
| US-4490369-A | HYPOTENSIVE, BRRADYCARDIAL | DR. KARL THOMAE GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1984-12-25 | — | — | US | disclosed |
| EP-0065229-A1 | Benzazepines, process for their preparation and their application as pharmaceutical preparations | Dr. Karl Thomae GmbH (DE) | 1982-11-24 | — | — | EP | disclosed |