SCHEMBL10980698

SCHEMBL10980698

CCCCN(Cc1cccnc1)c1ccc(C)cc1C

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.45
CHRNB2 P17787 2/20 0.44
CHRNA4 P43681 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
KDM4E B2RXH2 1/20 0.41
CRHR1 P34998 1/20 0.41
S1PR1 P21453 1/20 0.40
TSHR P16473 1/20 0.39
TRPM8 Q7Z2W7 1/20 0.39
CHRNA7 P36544 1/20 0.38
TP53 P04637 1/20 0.38
ALDH1A1 P00352 2/20 0.38
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
GRM2 Q14416 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10986150 0.79 S1PR1 (0.49) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1
SCHEMBL10558562 0.78 GRM2 (0.48) CYP3A4TSHRGRM2
SCHEMBL9287384 0.78 CHRNB2 (0.50) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1
SCHEMBL10995093 0.77 S1PR1 (0.47) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1
SCHEMBL10980311 0.75 S1PR1 (0.45) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1
SCHEMBL10986588 0.75 S1PR1 (0.45) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1
SCHEMBL10555995 0.73 CYP3A4 (0.60) CYP3A4CHRNB2CHRNA4KDM4ETSHR
SCHEMBL10980178 0.73 S1PR1 (0.56) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1
SCHEMBL11922687 0.72 CHRNB2 (0.72) CHRNB2CHRNA4TDP1L3MBTL1KDM4E
Hydrochloric Acid SCHEMBL10986448 0.72 S1PR1 (0.55) CYP3A4CHRNB2CHRNA4TDP1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4552960-A N,N-DISUBSTITUTED HETEROCYCLIC AMINES ELI LILLY AND COMPANY (US) 1985-11-12 US disclosed
EP-0129433-A2 Amines as fungicidal agents ELI LILLY AND COMPANY (US) 1984-12-27 EP disclosed