Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778573 | 0.84 | — | — | |
| SCHEMBL236881 | 0.81 | CYP2D6 (0.30) | — | |
| SCHEMBL2241191 | 0.81 | — | — | |
| SCHEMBL731008 | 0.79 | — | — | |
| SCHEMBL12466533 | 0.78 | KDM4E (0.33) | TDP1 | |
| SCHEMBL3446729 | 0.78 | RECQL (0.35) | POLBNOS3NOS1NOS2 | |
| SCHEMBL969556 | 0.77 | — | — | |
| SCHEMBL157427 | 0.75 | CYP2D6 (0.33) | TDP1 | |
| SCHEMBL1428236 | 0.75 | — | — | |
| SCHEMBL170248 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4491586-A | Amine derivatives | GLAXO GROUP LIMITED (GB) | 1985-01-01 | — | — | US | disclosed |
| EP-0029306-B1 | AMINOALKYL COMPOUNDS, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1984-07-25 | — | — | EP | disclosed |
| EP-0029306-A1 | Aminoalkyl compounds, their production and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1981-05-27 | — | — | EP | disclosed |