SCHEMBL12466533

SCHEMBL12466533

CN1CCN(C2CCC[N]2)CC1

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
TDP1 Q9NUW8 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2722168 0.94 KDM4E (0.32) KDM4ETDP1
SCHEMBL2778573 0.89
SCHEMBL236881 0.81 CYP2D6 (0.30)
SCHEMBL2241191 0.81
SCHEMBL731008 0.79
SCHEMBL7549219 0.79 KDM4E (0.35) KDM4ETDP1
SCHEMBL10982015 0.78 POLB (0.32) TDP1
SCHEMBL969556 0.77
SCHEMBL1428236 0.75
SCHEMBL157427 0.75 CYP2D6 (0.33) TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2668178-A1 NEW 5-ALKYNYL-PYRIDINES Boehringer Ingelheim International GmbH (DE) 2013-12-04 EP disclosed
WO-2012101184-A1 NEW 5-ALKYNYL-PYRIDINES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2012-08-02 WO disclosed