Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | PDE5A | O76074 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4474609 | 0.82 | MDM2 (0.62) | KDM4EHPGDBLMALDH1A1GLA | |
| SCHEMBL4471712 | 0.81 | ALDH1A1 (0.53) | KDM4EHPGDLMNACYP2C19ALDH1A1 | |
| SCHEMBL11008749 | 0.79 | MCL1 (0.51) | KDM4EHPGDLMNATSHRCYP2C19 | |
| SCHEMBL21051645 | 0.79 | GCGR (0.44) | KDM4EPDE3BPDE3AHPGDPDE5A | |
| SCHEMBL7365683 | 0.79 | KDM4E (0.51) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL9701575 | 0.79 | MDM2 (0.59) | KDM4EHPGDBLMALDH1A1GLA | |
| SCHEMBL11737297 | 0.79 | ERCC1 (0.57) | KDM4EHPGDLMNAALDH1A1GLA | |
| SCHEMBL7260450 | 0.76 | KDM4E (0.70) | KDM4EHPGDALDH1A1GLAGAA | |
| SCHEMBL11736292 | 0.76 | KDM4E (0.51) | KDM4EPDE3BPDE3AHPGDPDE5A | |
| SCHEMBL9524981 | 0.75 | KDM4E (0.54) | KDM4EPDE3BPDE3AHPGDPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-59025391-A | — | — | None | — | — | JP | disclosed |
| US-4497816-A | 7-(4-Pyridyl)-1,8-naphthyridine derivatives and their antibacterial compositions | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1985-02-05 | — | — | US | disclosed |
| JP-S5925391-A | PYRIDYLNAPHTHYRIDINE DERIVATIVE AND SALT THEREOF | DAINIPPON PHARMACEUT CO LTD | 1984-02-09 | — | — | JP | disclosed |
| US-3948903-A | Substituted N-(1,2-dihydro-2-oxonicotinyl)-cephalexins and -cephaloglycins | PARKE, DAVIS & COMPANY (US) | 1976-04-06 | — | — | US | disclosed |