Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PPARG | P37231 | 3/20 | 0.53 |
| ▸ | PPARA | Q07869 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CTSA | P10619 | 2/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15104584 | 0.83 | CTSA (0.51) | LMNASMN1; SMN2ALDH1A1CTSAEPHX2 | |
| SCHEMBL10992192 | 0.82 | EGLN1 (0.56) | SMN1; SMN2ALDH1A1CTSAUSP30HDAC1 | |
| SCHEMBL5849288 | 0.82 | SMN1; SMN2 (0.72) | LMNASMN1; SMN2ALDH1A1EPHX2HDAC3 | |
| SCHEMBL17510966 | 0.81 | HIF1A (0.71) | LMNASMN1; SMN2HIF1AHDAC3HDAC1 | |
| SCHEMBL19440878 | 0.80 | SMN1; SMN2 (0.47) | SMN1; SMN2CTSAUSP30HIF1AHDAC3 | |
| SCHEMBL24114406 | 0.80 | KMT2A (0.49) | SMN1; SMN2CTSAEPHX2USP30HIF1A | |
| SCHEMBL30765068 | 0.78 | SMN1; SMN2 (0.70) | LMNASMN1; SMN2ALDH1A1HIF1AKMT2A | |
| SCHEMBL27176218 | 0.78 | SMN1; SMN2 (0.70) | LMNASMN1; SMN2ALDH1A1HIF1AKMT2A | |
| SCHEMBL25262251 | 0.77 | CTSA (0.53) | CTSAUSP30HDAC1KMT2A | |
| SCHEMBL13299860 | 0.77 | HDAC3 (0.75) | LMNASMN1; SMN2ALDH1A1EPHX2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4555520-A | 2-Pyridylcarboxamides which inhibit arachidonic acid release | E. R. SQUIBB & SONS, INC. (US) | 1985-11-26 | — | — | US | claimed |
| US-4555520-A | 2-Pyridylcarboxamides which inhibit arachidonic acid release | E. R. SQUIBB & SONS, INC. (US) | 1985-11-26 | — | — | US | disclosed |