SCHEMBL10985227

SCHEMBL10985227

O=C1CCCC2CCC=CC12

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.30
CA2 P00918 1/20 0.30
CA4 P22748 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8639702 0.84 KMT2A (0.33) CA1CA2CA4
SCHEMBL17634358 0.76 CNR2 (0.30)
SCHEMBL13193143 0.73
SCHEMBL11799164 0.72 ALDH1A1 (0.30)
SCHEMBL7894905 0.72 KDM4E (0.30)
SCHEMBL17632950 0.72
SCHEMBL10892133 0.71
SCHEMBL9646957 0.69 MT-CO2 (0.33) CA1CA2CA4
SCHEMBL8635030 0.69 TLR4 (0.31)
SCHEMBL7999527 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4515720-A Method of synthesizing a late-stage intermediate to 11-deoxydaunorubicin and 11-deoxyadriamycin, and two precursors to the object intermediate OREGON GRADUATE CENTER FOR STUDY & RESEARCH (US) 1985-05-07 US claimed
US-4543428-A Production of a hexahydronaphthalenone compound OREGON GRADUATE CENTER FOR STUDY & RESEARCH (US) 1985-09-24 US disclosed
US-4543428-A Production of a hexahydronaphthalenone compound OREGON GRADUATE CENTER FOR STUDY & RESEARCH (US) 1985-09-24 US disclosed
US-4515720-A Method of synthesizing a late-stage intermediate to 11-deoxydaunorubicin and 11-deoxyadriamycin, and two precursors to the object intermediate OREGON GRADUATE CENTER FOR STUDY & RESEARCH (US) 1985-05-07 US disclosed
US-4499289-A ANTIATHEROSCLEROSIS G. D. SEARLE & CO. (US) 1985-02-12 US disclosed
EP-0111261-A2 Octahydronapthalenes G.D. Searle & Co. (US) 1984-06-20 EP disclosed