Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10832100 | 0.86 | ALDH1A1 (0.50) | ALDH1A1PAX8CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10983859 | 0.86 | ALDH1A1 (0.42) | ALDH1A1PAX8 | |
| SCHEMBL10980376 | 0.86 | ALDH1A1 (0.42) | ALDH1A1PAX8 | |
| SCHEMBL10989247 | 0.86 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL10978708 | 0.86 | ALDH1A1 (0.47) | ALDH1A1 | |
| SCHEMBL10989873 | 0.85 | BRD4 (0.43) | — | |
| SCHEMBL10986559 | 0.85 | KCNH2 (0.44) | ALDH1A1KCNH2HDAC1HSD17B10 | |
| SCHEMBL10990927 | 0.85 | ALDH1A1 (0.46) | ALDH1A1 | |
| SCHEMBL10924753 | 0.84 | BRD4 (0.47) | ALDH1A1KCNH2HDAC1CYP1A2CYP3A4 | |
| SCHEMBL10925793 | 0.81 | KCNH2 (0.44) | ALDH1A1KCNH2HDAC1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499279-A | ANTIDIABETIC AND HYPOGLYCEMIC AGENTS | SANDOZ, INC. (US) | 1985-02-12 | — | — | US | disclosed |
| US-4419353-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1983-12-06 | — | — | US | disclosed |
| US-4397850-A | HYPOGLYCEMIC, ANTIDIABETIC | SANDOZ, INC. (US) | 1983-08-09 | — | — | US | disclosed |
| US-4336379-A | ANTIDIABETIC AGENTS | SANDOZ, INC. (US) | 1982-06-22 | — | — | US | disclosed |