Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.83 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098676 | 1.00 | P2RX7 (0.83) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1099251 | 0.93 | P2RX7 (0.86) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1099254 | 0.93 | P2RX7 (0.86) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1098877 | 0.92 | P2RX7 (0.84) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1098874 | 0.92 | P2RX7 (0.84) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1099236 | 0.91 | P2RX7 (1.00) | P2RX7SMN1; SMN2HSD17B10CACNA1HPOLB | |
| SCHEMBL1100203 | 0.90 | P2RX7 (1.00) | P2RX7ROCK2SMN1; SMN2HSD17B10CACNA1H | |
| SCHEMBL1098421 | 0.89 | P2RX7 (0.79) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1098423 | 0.89 | P2RX7 (0.79) | P2RX7ROCK2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL1099960 | 0.88 | P2RX7 (0.88) | P2RX7SMN1; SMN2HSD17B10CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393781-B1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-8153809-B2 | Dihydropyridone ureas as P2X7 modulators | ROCHE PALO ALTO LLC (US) | 2012-04-10 | — | — | US | disclosed |
| EP-2393781-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. Hoffmann-La Roche AG (CH) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010072599-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |
| US-20100160388-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160388-A1 | DIHYDROPYRIDONE UREAS AS P2X7 MODULATORS | P2RY1, P2RX1, P2RX3 | P2RX7 5/4885ROCK2 4613/4885SMN1; SMN2 2596/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.