Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Phenyltoloxamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.55 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.44 |
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.44 |
| ▸ | ESR2 known ✓ | Q92731 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.78 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.55 |
| ▸ | DRD5 | P21918 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenyltoloxamine SCHEMBL158443 | 0.88 | KDM4E (1.00) | KDM4ELMNAHRH1DRD2DRD1 | |
| Phenyltoloxamine SCHEMBL29440538 | 0.78 | LMNA (0.77) | KDM4ELMNAHRH1DRD2DRD1 | |
| Citric Acid SCHEMBL11862593 | 0.78 | KDM4E (0.61) | KDM4ELMNAALDH1A1MEN1CYP1A2 | |
| Citric Acid SCHEMBL11862591 | 0.78 | KDM4E (0.61) | KDM4ELMNAALDH1A1MEN1CYP1A2 | |
| Phenyltoloxamine SCHEMBL5145512 | 0.74 | DRD1 (1.00) | KDM4ELMNAHRH1DRD2DRD1 | |
| Phenyltoloxamine SCHEMBL28854 | 0.74 | DRD1 (1.00) | KDM4ELMNAHRH1DRD2DRD1 | |
| Citric Acid SCHEMBL8657218 | 0.73 | KDM4E (0.70) | KDM4ELMNAHRH1DRD2DRD1 | |
| Phenyltoloxamine SCHEMBL16755246 | 0.73 | DRD1 (0.97) | KDM4ELMNAHRH1DRD2DRD1 | |
| Phenyltoloxamine SCHEMBL8510190 | 0.72 | HRH1 (1.00) | KDM4ELMNAHRH1DRD2DRD1 | |
| Diphenhydramine SCHEMBL8036949 | 0.71 | DRD1 (0.77) | KDM4ELMNAHRH1DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4493827-A | Method of inducing sleep | VALLE RONALD | 1985-01-15 | — | — | US | disclosed |