Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2781825 | 0.73 | KMT2A (0.40) | KMT2AHDAC3HDAC1 | |
| SCHEMBL109203 | 0.72 | SIRT6 (0.41) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL12124262 | 0.72 | SMYD3 (0.51) | SMYD3FDPSMEN1KMT2AALDH1A1 | |
| SCHEMBL107828 | 0.71 | SMYD3 (0.52) | SMYD3FDPSMEN1KMT2AKDM4E | |
| SCHEMBL108217 | 0.70 | NAMPT (0.42) | SMYD3FDPSALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL20190429 | 0.70 | SMYD3 (0.48) | SMYD3FDPSMEN1KMT2AHDAC3 | |
| SCHEMBL12124298 | 0.69 | POLB (0.54) | SMYD3MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL2629375 | 0.69 | SMYD3 (0.47) | SMYD3FDPSMEN1KMT2AKDM4E | |
| SCHEMBL12124245 | 0.69 | SMYD3 (0.47) | SMYD3FDPSMEN1KMT2AHDAC3 | |
| SCHEMBL12124304 | 0.68 | SMYD3 (0.47) | SMYD3FDPSMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125102-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |