Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109899 | 0.72 | SMYD3 (0.40) | NPC1RAB9ASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL16235935 | 0.71 | SIRT6 (0.52) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL106400 | 0.71 | PSMB8 (0.40) | NPC1RAB9ASMN1; SMN2CNR2ALDH1A1 | |
| SCHEMBL18130911 | 0.71 | SIRT6 (0.47) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL18130884 | 0.70 | SIRT6 (0.46) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL18130896 | 0.70 | SIRT6 (0.46) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL18130883 | 0.70 | SIRT6 (0.46) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL107632 | 0.69 | CTSA (0.46) | LMNANPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL932448 | 0.69 | SIRT6 (0.62) | SIRT6JUNNFKB1NFKB2RELA | |
| SCHEMBL31306894 | 0.69 | SIRT6 (0.62) | SIRT6JUNNFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125102-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |