Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TP53 | P04637 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10988413 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10991094 | 0.76 | ALDH1A1 (0.60) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10987505 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10983736 | 0.75 | SMN1; SMN2 (0.70) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10991342 | 0.71 | ALDH1A1 (0.57) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL19569166 | 0.71 | TP53 (0.60) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10988779 | 0.71 | SMN1; SMN2 (0.52) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL4470140 | 0.70 | RECQL (0.61) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10993565 | 0.69 | PDE10A (0.73) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 | |
| SCHEMBL10408657 | 0.68 | PDE10A (0.55) | SMN1; SMN2TP53NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4497814-A | 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-02-05 | — | — | US | claimed |