Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TET2 | Q6N021 | 6/20 | 0.35 |
| ▸ | TET3 | O43151 | 2/20 | 0.35 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.33 |
| ▸ | KDM4A | O75164 | 2/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.33 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL507453 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2TET2TET3TET1LMNA | |
| Malic Acid SCHEMBL8928445 | 0.82 | SMN1; SMN2 (0.75) | SMN1; SMN2TET2TET3TET1LMNA | |
| Guanidino Acetate SCHEMBL33970 | 0.82 | — | — | |
| Guanidino Acetate SCHEMBL27413696 | 0.82 | EGLN1 (0.41) | LMNATDP1SLC22A6ALDH1A1MAPT | |
| Aspartic Acid SCHEMBL1097076 | 0.81 | GRIK1 (0.38) | — | |
| Aspartic Acid SCHEMBL1097075 | 0.81 | GRIK1 (0.38) | — | |
| Guanidino Acetate SCHEMBL1096898 | 0.81 | TP53 (0.44) | LMNATDP1ALDH1A1MAPTPTGS2 | |
| Guanidino Acetate SCHEMBL20531119 | 0.80 | — | — | |
| Guanidino Acetate SCHEMBL3331092 | 0.80 | — | — | |
| Guanidino Acetate SCHEMBL19458353 | 0.80 | EGLN1 (0.39) | LMNATDP1SLC22A6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114027393-A | Preparation method of solid-state fermented feed | 安徽五粮泰生物工程股份有限公司 | 2022-02-11 | — | — | CN | disclosed |
| US-8536222-B2 | Addition compounds of guanidinoacetic acid | ALZCHEM AG (DE) | 2013-09-17 | — | — | US | disclosed |
| US-20120238629-A1 | ADDITION COMPOUNDS OF GUANIDINOACETIC ACID | ALZCHEM TROSTBERG GMBH (DE) | 2012-09-20 | — | — | US | disclosed |
| US-8153685-B2 | For use in dietary supplements, animal feeds, and cosmetics; bioavailability | ALZCHEM TROSTBERG GMBH (DE) | 2012-04-10 | — | — | US | disclosed |
| CN-101132786-B | Salts, addition compounds and complex compounds of guanidinoacetic acid | ALZCHEM TROSTBERG GMBH | 2011-04-13 | — | — | CN | disclosed |
| US-20080161387-A1 | Salts, Addition Compounds and Complex Compounds of Guinadinoacetic Acid | ALZCHEM TROSTBERG GMBH (DE) | 2008-07-03 | — | — | US | disclosed |
| CN-101132786-A | Salts, addition compounds and complex compounds of guanidinoacetic acid | ALZCHEM TROSTBERG GMBH (DE) | 2008-02-27 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238629-A1 | ADDITION COMPOUNDS OF GUANIDINOACETIC ACID | GCDH, PCCA, PC | SMN1; SMN2 826/4885TET2 956/4885TET3 564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.