Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.66 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.53 |
| ▸ | GCGR | P47871 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18902507 | 0.87 | HIF1A (0.66) | HIF1AEGLN1HDAC6HDAC3HDAC4 | |
| SCHEMBL3380686 | 0.82 | HDAC1 (0.51) | HIF1AEGLN1HDAC6LMNAHDAC3 | |
| SCHEMBL10102476 | 0.81 | HDAC3 (0.75) | HDAC6MAPK1LMNAHDAC3HDAC4 | |
| SCHEMBL13299860 | 0.81 | HDAC3 (0.75) | HDAC6MAPK1LMNAHDAC3HDAC4 | |
| SCHEMBL6387697 | 0.80 | MAPK1 (0.81) | HDAC6MAPK1LMNAHDAC3HDAC4 | |
| SCHEMBL69286 | 0.80 | EGLN1 (0.81) | HIF1AEGLN1 | |
| Hydrochloric Acid SCHEMBL3128502 | 0.80 | HDAC3 (0.73) | HDAC6MAPK1LMNAHDAC3HDAC4 | |
| SCHEMBL28344799 | 0.80 | HIF1A (1.00) | HIF1AEGLN1 | |
| SCHEMBL10989972 | 0.76 | LMNA (0.68) | HDAC6MAPK1LMNAHDAC3HDAC4 | |
| SCHEMBL28598668 | 0.76 | HIF1A (1.00) | HIF1AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4555520-A | 2-Pyridylcarboxamides which inhibit arachidonic acid release | E. R. SQUIBB & SONS, INC. (US) | 1985-11-26 | — | — | US | disclosed |