SCHEMBL10993232

SCHEMBL10993232

CC1=C(C(=O)OCCC#N)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OCCN(C)Cc2ccccc2)=C(C)N1

nearest known ligand 0.82

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 9/20 0.82
ADORA3 P0DMS8 4/20 0.82
LMNA P02545 3/20 0.82
CYP1A2 P05177 3/20 0.82
CYP3A4 P08684 3/20 0.82
CYP2D6 P10635 3/20 0.82
CYP2C9 P11712 3/20 0.82
CYP2C19 P33261 3/20 0.82
MAPT P10636 3/20 0.82
TDP1 Q9NUW8 3/20 0.82
TSHR P16473 2/20 0.82
ADRA2A P08913 2/20 0.82
TBXA2R P21731 2/20 0.82
ABCB1 P08183 2/20 0.82
NPC1 O15118 1/20 0.82
ABCC4 O15439 1/20 0.82
ABCB11 O95342 1/20 0.82
PGR P06401 1/20 0.82
CHRM2 P08172 1/20 0.82
HTR1A P08908 1/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL10554411 0.93 LMNA (0.93) CACNA1CADORA3LMNACYP1A2CYP3A4
SCHEMBL8215921 0.91 CACNA1C (0.89) CACNA1CADORA3LMNACYP1A2CYP3A4
SCHEMBL11844936 0.91 CACNA1C (0.89) CACNA1CADORA3LMNACYP1A2CYP3A4
SCHEMBL9765743 0.91 CACNA1C (0.89) CACNA1CADORA3LMNACYP1A2CYP3A4
Nicardipine SCHEMBL4309716 0.90 CYP1A2 (0.98) CACNA1CADORA3LMNACYP1A2CYP3A4
Nicardipine SCHEMBL4309711 0.90 CYP1A2 (0.98) CACNA1CADORA3LMNACYP1A2CYP3A4
Nicardipine SCHEMBL34278 0.90 CYP1A2 (1.00) CACNA1CADORA3LMNACYP1A2CYP3A4
Nicardipine SCHEMBL34279 0.90 CYP1A2 (1.00) CACNA1CADORA3LMNACYP1A2CYP3A4
SCHEMBL11841273 0.90 CACNA1C (0.87) CACNA1CADORA3LMNACYP1A2CYP3A4
SCHEMBL10747615 0.90 CACNA1C (0.87) CACNA1CADORA3LMNACYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4551467-A Vasodilating cyanoalkyl esters of 1,4-dihydropyridines BAYER AKTIENGESELLSCHAFT (DE) 1985-11-05 US disclosed
US-4483985-A ALKALINE HYDROLYSIS OF ESTER GROUP BAYER AKTIENGESELLSCHAFT (DE) 1984-11-20 US disclosed
US-4285955-A CARDIOTONIC, HYPOTENSIVE, AND ANTISPASMOTIC AGENTS; VASODILATION BAYER AKTIENGESELLSCHAFT (DE) 1981-08-25 US disclosed