Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19981418 | 0.82 | MAPT (0.64) | MAPTLMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL10979786 | 0.77 | MEN1 (0.61) | MAPTLMNASMN1; SMN2GAAKMT2A | |
| SCHEMBL11183549 | 0.74 | MAPT (0.57) | MAPTSMN1; SMN2NPC1KMT2AGCK | |
| SCHEMBL11217720 | 0.72 | ALDH1A1 (0.61) | MAPTSMN1; SMN2NPC1KMT2AGCK | |
| SCHEMBL21232167 | 0.71 | HDAC4 (0.65) | SMN1; SMN2NPC1RAB9AALDH1A1MAPK1 | |
| SCHEMBL9416788 | 0.71 | SMN1; SMN2 (0.59) | MAPTLMNASMN1; SMN2GAANPC1 | |
| SCHEMBL6860113 | 0.69 | — | — | |
| SCHEMBL10412422 | 0.69 | HDAC1 (0.47) | MAPTLMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL9331716 | 0.69 | HDAC1 (0.47) | MAPTLMNAHTTSMN1; SMN2NPC1 | |
| SCHEMBL1022149 | 0.68 | RAB9A (0.59) | MAPTLMNASMN1; SMN2GAANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4535081-A | Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4423048-A | Antiallergic and antiulcer 1-oxo-1H-thiazolo[3,2-a]pyrimidine-2-carboxamides and intermediates therefor | PFIZER INC. (US) | 1983-12-27 | — | — | US | disclosed |
| US-4414388-A | ANTIALLERGENS, ANTIULCER AGENTS | PFIZER INC. (US) | 1983-11-08 | — | — | US | disclosed |