Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 4/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10994231 | 0.85 | SMN1; SMN2 (0.40) | SLC6A4SLC6A2SMN1; SMN2 | |
| SCHEMBL10984361 | 0.82 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL10991356 | 0.82 | HTR2A (0.38) | SLC6A4SMN1; SMN2HTR2AHRH1KDM4E | |
| SCHEMBL10989070 | 0.82 | SLC6A2 (0.43) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL10993650 | 0.81 | SLC6A4 (0.39) | SLC6A4SLC6A2SMN1; SMN2SLC6A3HTR2A | |
| SCHEMBL10994299 | 0.81 | SLC6A4 (0.42) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL10991194 | 0.81 | KDM4E (0.38) | SLC6A4SMN1; SMN2HTR2AHRH1KDM4E | |
| SCHEMBL10990798 | 0.81 | SLC6A2 (0.42) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 | |
| SCHEMBL10995377 | 0.77 | GAA (0.35) | SLC6A4SLC6A2SMN1; SMN2SLC6A3HTR2A | |
| SCHEMBL10989315 | 0.77 | ADRA2A (0.44) | SLC6A4SLC6A2SLC6A3HTR2AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500541-A | Pharmacologically active cyclopropane derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-02-19 | — | — | US | disclosed |
| EP-0039771-B1 | CYCLOPROPANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION | MERCK PATENT GmbH (DE) | 1983-10-19 | — | — | EP | disclosed |