Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10987631 | 0.84 | LMNA (0.40) | KDM4ETSHRLMNAGAAMAPT | |
| SCHEMBL10989070 | 0.84 | SLC6A2 (0.43) | KDM4EALDH1A1HTR2AHRH1CA1 | |
| SCHEMBL10984361 | 0.84 | SLC6A2 (0.43) | KDM4EALDH1A1HTR2AHRH1TP53 | |
| SCHEMBL10991356 | 0.84 | HTR2A (0.38) | KDM4EALDH1A1HTR2AHRH1HTR7 | |
| SCHEMBL10994299 | 0.83 | SLC6A4 (0.42) | KDM4EALDH1A1HTR2AHRH1LMNA | |
| SCHEMBL10990798 | 0.83 | SLC6A2 (0.42) | KDM4EALDH1A1HTR2AHRH1SLC6A4 | |
| SCHEMBL10993499 | 0.81 | SLC6A4 (0.39) | KDM4EALDH1A1HTR2AHRH1HTR7 | |
| SCHEMBL10985735 | 0.80 | ALDH1A1 (0.40) | KDM4EALDH1A1HTR2AHRH1TSHR | |
| SCHEMBL10995932 | 0.80 | SLC6A4 (0.40) | KDM4EHTR2AHRH1CA1CA2 | |
| SCHEMBL10995377 | 0.80 | GAA (0.35) | KDM4EALDH1A1HTR2AHRH1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4500541-A | Pharmacologically active cyclopropane derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1985-02-19 | — | — | US | disclosed |
| EP-0039771-B1 | CYCLOPROPANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES FOR THEIR PRODUCTION | MERCK PATENT GmbH (DE) | 1983-10-19 | — | — | EP | disclosed |
| EP-0039771-A1 | Cyclopropane derivatives, pharmaceutical compositions containing them and processes for their production | MERCK PATENT GmbH (DE) | 1981-11-18 | — | — | EP | disclosed |