SCHEMBL10995248

SCHEMBL10995248

CNC=C(C(=O)C=Cc1ccc(Cl)cc1)C(=O)OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.47
TP53 P04637 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
PKM P14618 1/20 0.46
TSHR P16473 1/20 0.46
NFKB1 P19838 1/20 0.46
MAPK1 P28482 1/20 0.46
CYP2C19 P33261 1/20 0.46
THPO P40225 1/20 0.46
MEN1 O00255 1/20 0.46
NPC1 O15118 1/20 0.46
GMNN O75496 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MAPT P10636 1/20 0.46
RAB9A P51151 1/20 0.46
BLM P54132 1/20 0.46
PMP22 Q01453 1/20 0.46
KMT2A Q03164 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10995247 1.00 CYP1A2 (0.47) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL11348952 0.95 CYP1A2 (0.43) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL10991729 0.85 NOS2 (0.45) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL10991725 0.85 NOS2 (0.45) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL7077101 0.83 CYP1A2 (0.58) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL7077102 0.83 CYP1A2 (0.58) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL10995524 0.82 ALDH1A1 (0.51) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL10995520 0.82 ALDH1A1 (0.51) CYP1A2TP53CYP3A4CYP2D6PKM
SCHEMBL10759095 0.81 NOS2 (0.46) TP53CYP3A4CYP2D6PKMTSHR
SCHEMBL28347012 0.74 CYP1A2 (0.75) CYP1A2TP53CYP3A4MAPK1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4549022-A ANTIBACTERIAL AGENT; STIMULANT ON CENTRAL NERVOUS SYSTEM HOFFMANN-LA ROCHE INC. (US) 1985-10-22 US disclosed
US-4521535-A ANTIBACTERIAL AGENTS; STIMULANTS FOR CENTRAL NERVOUS SYSTEM HOFFMANN-LA ROCHE INC. (US) 1985-06-04 US disclosed