Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.56 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 9/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | TTK | P33981 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998796 | 0.85 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10998912 | 0.84 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11000905 | 0.83 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10995889 | 0.83 | AURKA (0.67) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10995911 | 0.82 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11035255 | 0.81 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10999252 | 0.79 | AURKB (0.69) | KDM4EALDH1A1HPGDAURKATTK | |
| SCHEMBL10842808 | 0.78 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10707443 | 0.76 | MCL1 (0.63) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10998400 | 0.76 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBMCL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4514400-A | Cardiotonic 5-heteroaryl-pyridone | WILLIAM H. RORER, INC. (US) | 1985-04-30 | — | — | US | disclosed |