Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | AURKA | O14965 | 4/20 | 0.59 |
| ▸ | TTK | P33981 | 4/20 | 0.59 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.59 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.59 |
| ▸ | THRB | P10828 | 2/20 | 0.59 |
| ▸ | CASP1 | P29466 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992941 | 0.83 | TTK (0.60) | MAPTAURKATTKAURKBINCENP | |
| SCHEMBL10992087 | 0.81 | CDC7 (0.50) | MAPTLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL10887360 | 0.79 | KDM4E (0.63) | MAPTLMNAALDH1A1KDM4EHPGD | |
| SCHEMBL11170232 | 0.79 | TDP1 (0.59) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10994497 | 0.78 | TTK (0.71) | MAPTAURKATTKAURKBINCENP | |
| SCHEMBL10999463 | 0.78 | MAPT (0.53) | MAPTAURKATTKAURKBINCENP | |
| SCHEMBL11153190 | 0.77 | MAPT (0.56) | MAPTLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL6738366 | 0.77 | TSHR (0.76) | MAPTLMNAALDH1A1MEN1ALOX15 | |
| SCHEMBL10992852 | 0.76 | AURKB (0.67) | MAPTAURKATTKAURKBINCENP | |
| SCHEMBL11645181 | 0.76 | ALDH1A1 (0.61) | MAPTAURKATTKAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4559352-A | 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4515797-A | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-07 | — | — | US | disclosed |
| EP-0061774-A2 | 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1982-10-06 | — | — | EP | disclosed |