Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 8/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 8/20 | 0.53 |
| ▸ | INCENP | Q9NQS7 | 8/20 | 0.53 |
| ▸ | AURKA | O14965 | 7/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998515 | 0.84 | PDGFRB (0.47) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL10992941 | 0.81 | TTK (0.60) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL10998585 | 0.80 | MAPT (0.41) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL10890451 | 0.78 | MCL1 (0.58) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL10996778 | 0.78 | MAPT (0.59) | MAPTMEN1KMT2ATTKAURKB | |
| SCHEMBL10992852 | 0.77 | AURKB (0.67) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL3976788 | 0.76 | TDP1 (0.64) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL3973537 | 0.74 | MAPT (0.69) | MAPTTDP1MEN1KMT2APOLB | |
| SCHEMBL10992408 | 0.73 | AURKB (0.72) | MAPTTDP1MEN1KMT2ATTK | |
| SCHEMBL11000688 | 0.72 | TTK (0.61) | MAPTMEN1KMT2ATTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4559352-A | 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4515797-A | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-07 | — | — | US | disclosed |