Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 9/20 | 0.46 |
| ▸ | CA12 | O43570 | 7/20 | 0.46 |
| ▸ | CTNNB1 | P35222 | 3/20 | 0.37 |
| ▸ | WNT3A | P56704 | 3/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | EPM2A | O95278 | 1/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | CDC14A | Q9UNH5 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468448 | 0.79 | CA2 (0.55) | CA2CA12CYP2A6 | |
| SCHEMBL10997195 | 0.71 | TAS1R3 (0.40) | CA2CA12CTNNB1WNT3ACHRM5 | |
| SCHEMBL12135783 | 0.71 | CA2 (0.51) | CA2CA12CTNNB1WNT3AHTR1B | |
| SCHEMBL3796719 | 0.71 | CYP2A6 (0.47) | CA2CA12CTNNB1WNT3AHTR1B | |
| Hydrochloric Acid SCHEMBL27659768 | 0.70 | CYP2A6 (0.46) | CA2CA12CTNNB1WNT3ACHRM5 | |
| Hydrochloric Acid SCHEMBL27827959 | 0.70 | CYP2A6 (0.46) | CA2CA12CTNNB1WNT3ACHRM5 | |
| SCHEMBL38663112 | 0.68 | CA2 (0.39) | CA2CA12CTNNB1WNT3ACHRM5 | |
| SCHEMBL692366 | 0.68 | CYP2A6 (0.47) | CA2CA12CTNNB1WNT3AEPM2A | |
| SCHEMBL9075377 | 0.68 | CA2 (0.51) | CA2CA12EPM2APTPRCPTPN6 | |
| SCHEMBL17955745 | 0.68 | CYP2A6 (0.47) | CA2CA12CTNNB1WNT3AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544667-A | CARBONIC ANHYDRASE INHIBITOR; VISION DEFECTS | MERCK & CO., INC. (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0152340-A1 | 2-Sulfamoylbenzo[b]furan derivatives and ophtalmic composition for the treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1985-08-21 | — | — | EP | disclosed |