Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.33 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10992871 | 0.81 | KIF11 (0.46) | KIF11CYP2C19HIF1AALDH1A1CYP1A2 | |
| SCHEMBL10998617 | 0.79 | KIF11 (0.42) | KIF11CYP2C19HIF1AALDH1A1CYP1A2 | |
| SCHEMBL6535389 | 0.76 | KCNN4 (0.42) | KIF11PTGS2CYP2C19HIF1AALDH1A1 | |
| SCHEMBL10997360 | 0.75 | KIF11 (0.49) | KIF11CYP2C19HIF1AALDH1A1CYP1A2 | |
| SCHEMBL11360741 | 0.70 | CHRM2 (0.43) | KIF11CYP2C19HIF1APLOD2PLOD3 | |
| Pyridine SCHEMBL8673561 | 0.66 | CYP1A2 (0.39) | KIF11CYP2C19HIF1AALDH1A1CYP1A2 | |
| SCHEMBL28320432 | 0.66 | CYP19A1 (0.54) | KIF11CYP19A1 | |
| SCHEMBL5580426 | 0.65 | KIF11 (0.64) | KIF11CYP2C19ALDH1A1 | |
| SCHEMBL10234508 | 0.65 | CYP2C19 (0.46) | KIF11CYP2C19HIF1AALDH1A1CYP1A2 | |
| SCHEMBL8695362 | 0.65 | KIF11 (0.46) | KIF11CYP2C19HIF1APLOD2PLOD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4535084-A | ANTIARTHRITIC, ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1985-08-13 | — | — | US | disclosed |
| US-4246263-A | ANTIARTHRITIC AGENTS | PFIZER INC. (US) | 1981-01-20 | — | — | US | disclosed |