Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | NPC1 | O15118 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | FABP3 | P05413 | 1/20 | 0.44 |
| ▸ | FABP1 | P07148 | 1/20 | 0.44 |
| ▸ | FABP2 | P12104 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000007 | 0.82 | MEN1 (0.47) | KDM4EMAPTNPC1ALDH1A1HPGD | |
| SCHEMBL1226967 | 0.78 | ALDH1A1 (0.54) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL11005789 | 0.74 | MAPT (0.60) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL11002552 | 0.74 | KDM4E (0.56) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL10999906 | 0.73 | MAPT (0.55) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL11000951 | 0.73 | KDM4E (0.74) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL6668551 | 0.73 | MAPT (0.55) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL10999126 | 0.73 | ALDH1A1 (0.52) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL11004746 | 0.73 | ALDH1A1 (0.47) | KDM4EMAPTNPC1ALDH1A1NPSR1 | |
| SCHEMBL11003590 | 0.73 | HSD17B10 (0.50) | KDM4EMAPTNPC1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544752-A | TREATMENT OF GOUT; ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0048615-B1 | IMPROVEMENTS IN OR RELATING TO 3-ARYL-5-ISOTHIAZOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4346094-A | ENZYME INHIBITORS | ELI LILLY AND COMPANY (US) | 1982-08-24 | — | — | US | disclosed |
| EP-0048615-A1 | Improvements in or relating to 3-aryl-5-isothiazole derivatives | ELI LILLY AND COMPANY (US) | 1982-03-31 | — | — | EP | disclosed |