Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.43 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998752 | 0.82 | KDM4E (0.56) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL11003366 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL5156927 | 0.76 | MEN1 (0.47) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL10268828 | 0.72 | KDM4E (0.49) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL11003497 | 0.70 | RAB9A (0.47) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL11003416 | 0.70 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL10994400 | 0.70 | KDM4E (0.64) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL10994158 | 0.70 | MAPT (0.47) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL8842879 | 0.70 | MKNK1 (0.48) | ALDH1A1KDM4EMAPTGAAHSD17B10 | |
| SCHEMBL10999458 | 0.70 | MKNK1 (0.47) | MEN1KMT2AALDH1A1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4544752-A | TREATMENT OF GOUT; ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1985-10-01 | — | — | US | disclosed |
| EP-0048615-B1 | IMPROVEMENTS IN OR RELATING TO 3-ARYL-5-ISOTHIAZOLE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1984-05-30 | — | — | EP | disclosed |
| US-4346094-A | ENZYME INHIBITORS | ELI LILLY AND COMPANY (US) | 1982-08-24 | — | — | US | disclosed |
| EP-0048615-A1 | Improvements in or relating to 3-aryl-5-isothiazole derivatives | ELI LILLY AND COMPANY (US) | 1982-03-31 | — | — | EP | disclosed |