Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.33 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 8/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HNF4A | P41235 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24051152 | 0.87 | PDCD1 (0.53) | PDCD1CD274ALDH1A1HSD17B10HPGD | |
| SCHEMBL21172870 | 0.83 | CD274 (0.47) | PDCD1CD274ALDH1A1HSD17B10HPGD | |
| Propionic Acid SCHEMBL4423846 | 0.78 | CD274 (0.50) | PDCD1CD274ALDH1A1SMN1; SMN2HNF4A | |
| SCHEMBL25785668 | 0.72 | PDCD1 (0.64) | PDCD1CD274ALDH1A1HSD17B10HPGD | |
| SCHEMBL21172871 | 0.71 | PDCD1 (0.44) | PDCD1CD274ALDH1A1HSD17B10HPGD | |
| SCHEMBL10304866 | 0.71 | PTGS2 (0.42) | PDCD1CD274HTR7 | |
| Iodide SCHEMBL28397643 | 0.69 | PDCD1 (0.55) | PDCD1CD274ALDH1A1HSD17B10HPGD | |
| SCHEMBL13760020 | 0.68 | ACHE (0.39) | PDCD1CD274ALDH1A1SMN1; SMN2 | |
| SCHEMBL10568634 | 0.68 | PDCD1 (0.55) | PDCD1CD274ALDH1A1HSD17B10HPGD | |
| SCHEMBL13368945 | 0.68 | ABL1 (0.50) | PDCD1CD274HTR7BACE1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4554360-A | DIARYLIODONIUM SALT, IODOARENE, COUPLING | NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) | 1985-11-19 | — | — | US | disclosed |