Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10994257 | 0.91 | ALDH1A1 (0.39) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10991901 | 0.90 | LMNA (0.42) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10986882 | 0.90 | MAPT (0.41) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10994839 | 0.89 | FFAR1 (0.35) | ALDH1A1CYP2C9 | |
| SCHEMBL10986638 | 0.88 | IGF1R (0.40) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10991237 | 0.88 | ALDH1A1 (0.39) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10989685 | 0.87 | CHRM2 (0.44) | ALDH1A1LMNASMN1; SMN2KMT2ACYP2D6 | |
| SCHEMBL10996382 | 0.86 | LMNA (0.39) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10994791 | 0.86 | ALDH1A1 (0.37) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 | |
| SCHEMBL10996165 | 0.85 | TEAD1 (0.42) | ALDH1A1MAPTLMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4558129-A | Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade | SYNTEX (U.S.A.) INC. (US) | 1985-12-10 | — | — | US | disclosed |