Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11000490 | 1.00 | MAPT (0.43) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL10222900 | 0.89 | VCAM1 (0.46) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL573657 | 0.89 | VCAM1 (0.46) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL574029 | 0.89 | VCAM1 (0.46) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL11002863 | 0.88 | MAPT (0.44) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL11002861 | 0.88 | MAPT (0.44) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL11509690 | 0.87 | VCAM1 (0.43) | MAPTVCAM1KMT2AMEN1POLB | |
| SCHEMBL10997441 | 0.86 | ALDH1A1 (0.39) | MAPTKMT2AMEN1ALDH1A1ALPL | |
| SCHEMBL10997448 | 0.86 | ALDH1A1 (0.39) | MAPTKMT2AMEN1ALDH1A1ALPL | |
| SCHEMBL11517426 | 0.86 | VCAM1 (0.46) | MAPTVCAM1KMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4492710-A | Substituted pyrrolidinyl-benzoic acid derivatives and a process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-01-08 | — | — | US | disclosed |