Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.63 |
| ▸ | CA1 | P00915 | 4/20 | 0.63 |
| ▸ | FOLH1 | Q04609 | 9/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 3/20 | 0.49 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.49 |
| ▸ | TYMS | P04818 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27564186 | 0.89 | CA2 (0.75) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL3279421 | 0.87 | CA2 (0.61) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL17517569 | 0.85 | CA2 (0.59) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL16243376 | 0.83 | CA2 (0.61) | CA2CA1CA12CA9 | |
| SCHEMBL698067 | 0.83 | CA2 (0.67) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL715646 | 0.83 | CA2 (0.67) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL97498 | 0.83 | CA2 (0.67) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL5187907 | 0.82 | CA2 (0.66) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL9388610 | 0.82 | CA2 (0.66) | CA2CA1FOLH1CA12CA9 | |
| SCHEMBL11441221 | 0.82 | FOLH1 (0.80) | CA2CA1FOLH1CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4532241-A | Inhibiting neoplastic growth | SRI INTERNATIONAL (US) | 1985-07-30 | — | — | US | disclosed |
| US-4460591-A | ANTITUMOR AGENTS | SRI INTERNATIONAL (US) | 1984-07-17 | — | — | US | disclosed |