SCHEMBL715646

SCHEMBL715646

O=C(O)CC[C@@H](NC(=O)c1ccccc1)C(=O)O

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA2 P00918 4/20 0.67
CA1 P00915 3/20 0.67
TDP1 Q9NUW8 1/20 0.63
LMNA P02545 1/20 0.63
HSD17B10 Q99714 1/20 0.63
FOLH1 Q04609 3/20 0.60
NAALAD2 Q9Y3Q0 3/20 0.60
GAA P10253 1/20 0.59
HPGD P15428 2/20 0.58
KDM4E B2RXH2 1/20 0.58
CA12 O43570 1/20 0.56
CA9 Q16790 1/20 0.56
GGH Q92820 1/20 0.56
RIMKLA Q8IXN7 1/20 0.56
ADAMTS4 O75173 1/20 0.54
ADAMTS5 Q9UNA0 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL698067 1.00 CA2 (0.67) CA2CA1TDP1LMNAHSD17B10
SCHEMBL97498 1.00 CA2 (0.67) CA2CA1TDP1LMNAHSD17B10
SCHEMBL28286177 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
SCHEMBL28184998 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
SCHEMBL28287497 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
SCHEMBL28286179 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
SCHEMBL28185002 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
SCHEMBL4618531 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
Ammonia Solution, Strong SCHEMBL28375957 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10
SCHEMBL28287499 0.98 CA2 (0.65) CA2CA1TDP1LMNAHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024006841-A2 COMPOSITIONS FOR WEIGHT LOSS AND CANCER TREATMENT KNOWLEDGE PHARMACEUTICALS INC. (US) 2024-01-04 WO disclosed
US-20220296584-A1 Membrane Active Molecules KNOWLEDGE PHARMACEUTICALS INC. 2022-09-22 US disclosed
EP-3973997-A1 MEMBRANE ACTIVE MOLECULES Branequest, Inc. (US) 2022-03-30 EP disclosed
US-11186541-B2 Potent inhibitors of aspartate N-acetyl-transferase for the treatment of Canavan disease THE UNIVERSITY OF TOLEDO (US) 2021-11-30 US disclosed
US-20210307325-A1 COMPOUNDS AND METHODS OF REDUCING NEMATODE INFECTION IN PLANTS SONG BAO HUA (US) 2021-10-07 US disclosed
US-20200375958-A1 MEMBRANE ACTIVE MOLECULES KNOWLEDGE PHARMACEUTICALS INC. 2020-12-03 US disclosed
US-20200345006-A1 METHODS OF REDUCING NEMATODE INFECTION IN PLANTS UNIV NORTH CAROLINA CHARLOTTE (US) 2020-11-05 US disclosed
US-20200270202-A1 POTENT INHIBITORS OF ASPARTATE N-ACETYL-TRANSFERASE FOR THE TREATMENT OF CANAVAN DISEASE THE UNIVERSITY OF TOLEDO (US) 2020-08-27 US disclosed
EP-3615084-A1 MEMBRANE ACTIVE MOLECULES Branequest, Inc. (US) 2020-03-04 EP disclosed
WO-2018200412-A1 MEMBRANE ACTIVE MOLECULES BraneQuest, Inc. (US) 2018-11-01 WO disclosed
US-4072711-A ANIMAL GROWTH REGULATORS AMERICAN CYANAMID COMPANY (US) 1978-02-07 US disclosed
US-4062856-A ANIMAL GROWTH REGULATOR, HERBICIDE AMERICAN CYANAMID CO. (US) 1977-12-13 US disclosed
US-4051183-A 1-BENZOYL-3-(1,2,3,4-TETRAHYDRO-4-OXO-1-NAPHTHYL)-UREA, A NOVEL AND USEFUL INTERMEDIATE FOR THE PREPARATION OF ANIMAL GROWTH PROMOTING AGENTS AMERICAN CYANAMID COMPANY (US) 1977-09-27 US disclosed
US-4041070-A ANIMAL GROWTH PROMOTERS, ENHANCING FEED EFFICIENCY AMERICAN CYANAMID COMPANY (US) 1977-08-09 US disclosed
US-4036979-A ANIMAL GROWTH RATE ACCELERATOR AMERICAN CYANAMID COMPANY (US) 1977-07-19 US disclosed
US-4005140-A ANIMAL GROWTH REGULATORS, HERBICIDES AMERICAN CYANAMID COMPANY (US) 1977-01-25 US disclosed
US-3994924-A ANIMAL GROWTH PROMOTERS AMERICAN CYANAMID COMPANY (US) 1976-11-30 US disclosed
US-3993677-A ANIMAL GROWTH REGULATORS, HERBICIDES AMERICAN CYANAMID COMPANY (US) 1976-11-23 US disclosed
US-3953506-A ANIMAL GROWTH REGULATORS, HERBICIDES AMERICAN CYANAMID COMPANY (US) 1976-04-27 US disclosed
US-3953606-A ANIMAL GROWTH STIMULATORS AMERICAN CYANAMID COMPANY (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200270202-A1 POTENT INHIBITORS OF ASPARTATE N-ACETYL-TRANSFERASE FOR THE TREATMENT OF CANAVAN DISEASE GOT1, ACAT1, GOT2 CA2 1887/4885CA1 1312/4885TDP1 349/4885
US-20220296584-A1 Membrane Active Molecules GABRP, GRIN3A, GRIN2A CA2 519/4885CA1 240/4885TDP1 3276/4885
US-11186541-B2 Potent inhibitors of aspartate N-acetyl-transferase for the treatment of Canavan disease GOT1, ACAT1, GOT2 CA2 1887/4885CA1 1312/4885TDP1 349/4885
US-20200375958-A1 MEMBRANE ACTIVE MOLECULES GABRP, GRIN3A, GRIN2A CA2 519/4885CA1 240/4885TDP1 3276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.