Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | TTK | P33981 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | MAP3K14 | Q99558 | 3/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998796 | 0.84 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10998912 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11000282 | 0.81 | AURKB (0.61) | KDM4EALDH1A1HPGDAURKATTK | |
| SCHEMBL11002430 | 0.81 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10998595 | 0.78 | AURKA (0.43) | AURKATTKAURKBINCENP | |
| SCHEMBL10995889 | 0.78 | AURKA (0.67) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11000905 | 0.78 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10842808 | 0.75 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL11000777 | 0.74 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBMCL1KDM4E | |
| SCHEMBL10996854 | 0.74 | MAPT (0.41) | KDM4EALDH1A1AURKATTKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4514400-A | Cardiotonic 5-heteroaryl-pyridone | WILLIAM H. RORER, INC. (US) | 1985-04-30 | — | — | US | disclosed |